发给老马备查:
N, B+ I+ q. O. t; [3 M滴水察海(69304838) 15:23:23
- g5 Z1 _' j+ H8 X( B) k老马,我看到培美和S-1都提到TS低表达,而鳞多半不是低表达,是不是S-1不靠谱
4 R6 ^% M" d. y2 W+ [# A吉非替尼和S-1连用的依据
* u# k4 c+ q9 yGefitinib induced down-regulation of thymidylate synthase and E2F-1 in gefitinib-resistant NSCLC cells with MET amplification but not in those harboring the T790M mutation of EGFR. The combination of 5-fluorouracil and gefitinib synergistically inhibited the proliferation of cells with MET amplification, but not that of those with the T790M mutation of EGFR, in vitro.
' e4 ?% \5 h' g1 I0 @8 w是不是说因C-MET引起的耐药中,吉非替尼会引导TS低表达
% a% A# y6 r2 @; `. i0 w4 l这样是不是推理出,耐药后,可以用S-1和培美了?7 V; n( J8 D" {- o A
结论:
! n" k6 I e: H: L如果是T790M突变引起的耐药,则2992有效,如果是C-MET扩增引起的突变,则除了184,还可以特+S1联用,而且可能可以用培美。 |